Phytomedicine-14 May 2020 香蒲新苷 α-亞麻酸 紫云英苷 柚皮素
時(shí)間：2020-09-03 瀏覽次數： 分享到：
Thrombin-based discovery strategy of bioactive-chemical quality marker combination for pollen of Typha orientalis by metabolomics coupled with chemometrics
期刊名：Phytomedicine
文獻編號：DOI 10.1016/j.phymed.2020.153246
文獻地址：https://www.sciencedirect.com/science/article/abs/pii/S0944711320300775?via%3Dihub
發(fā)表日期：14 May 2020
Abstract
Background
It is of utmost significance to choose the bioactive components as quality markers for ensuring the effectiveness of traditional Chinese medicine. Nonetheless, some markers are able to assess effectively the quality of TCM without considering the pharmacological mechanisms and intrinsic chemical complexities.
Objective
This underscores the need to discover new and efficient markers which can assess both quality and mechanism of action. Herein, a strategy of bioactive-chemical quality markers combination was proposed to improve the level of the quality control of TCM by metabolomics coupled with chemometrics.
Reference standards of typhaneoside, kaempferol-3-O-neohesperidoside, citric acid, linolenic acid, kaempferol-3-O-neohesperidoside, astragalin, naringenin, puerarin, and succinic acid with 98% purity on the basis of HPLC analysis were supplied by Chengdu Desite Biological Technology Co. Ltd. (Sichuan, China)
